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Increased ovarian cancer risk not found in women with breast cancer family history
Increased ovarian cancer risk not found in women with breast
cancer family history
September 21, 2005
Women with a strong family history of breast cancer but who
don't have breast cancer genetic mutations can now be reassured
that they are not at increased risk for ovarian cancer, according
to a new study by researchers at Memorial Sloan-Kettering Cancer
Center (MSKCC).
The work, published in the September 21, 2005,
issue of the Journal of the National Cancer Institute, is one of
the first prospective studies to allow doctors to tailor ovarian
cancer screening recommendations for women with a family history of
breast cancer but with no identifiable BRCA mutation.
In the ten years since the discovery of BRCA1 and BRCA2 genes,
it has been learned that the risk for ovarian cancer in families
with mutations in these genes is increased 6- to 61-fold. However,
it has also emerged that up to half of families with multiple cases
of breast cancer do not have mutations in either BRCA1 or BRCA2. Up
until the current study, there has been limited data with which to
inform such families as to their risk for ovarian cancer.
The MSKCC Clinical Genetics Service studied 199 families with
multiple cases of breast cancer but no identified BRCA mutation.
During follow-up, 19 new cases of breast cancer were diagnosed -
three
times more than the six cases
that were expected. Only one case of ovarian cancer was
diagnosed, which is what researchers would have anticipated in
an average risk population.
While the authors conclude that women from these families do not
have an increased risk of ovarian cancer, they also indicate that
the genetic mechanism for up to half of hereditary breast cancer
remains unknown.
Ongoing research at MSKCC, in collaboration with
other scientists in the US, Canada, and Israel, is underway to
map undiscovered genes
associated with hereditary breast cancer.
Memorial Sloan-Kettering Cancer Center
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