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Screening may over-diagnose 1 in 10 breast cancers
Screening may over-diagnose 1 in 10 breast cancers
March 03, 2006
Rate of overdiagnosis of breast cancer 15
years after the end of Malmö
mammographic screening trial: Follow-up study BMJ online
first
Screening women for breast cancer could result in a 10% rate of
over-diagnosis, finds a study published online by the BMJ
today.
Although it is widely agreed that breast screening can reduce
deaths, more discussion around this negative side effect of
screening is needed, say the authors.
Researchers analysed the rate of over-diagnosis of breast cancer
using data from a large breast screening trial conducted in Sweden
between 1976 and 1986. Over-diagnosis is defined as cases that
would never have come to clinical attention without screening.
They followed trial participants until December 2001, 15 years
after the trial ended using national registries to track survival
and detection of breast cancer.
Fifteen years after the end of the trial, the rate of
over-diagnosis of breast cancer was 10% in women randomised to
screening at age 55-69 years compared with an unscreened control
group.
Although earlier studies on over-diagnosis have shown rates of
up to 54%, a recent study suggests a much lower rate of 1%. But
none of these studies were based on direct observations, like the
present one, say the authors.
"It is widely agreed that screening using mammography can reduce
mortality in breast cancer.
The rate of over-diagnosis is another
issue to be considered in the ongoing discussion about clinical and
public
health implications of breast
cancer screening," they conclude.
An editorial in this week's BMJ discusses the UK breast
screening programme and concludes that, although breast screening
by mammography is far from perfect, it does save lives.
BMJ-British Medical Journal
[ Comment, Edit or Article Submission ]
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