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Study demonstrates role of exercise in modifying melatonin levels
Study demonstrates role of exercise in modifying melatonin
levels
December 02, 2005
Moderate physical activity, which is believed to help reduce the
risk of breast cancer, may do so because it increases production of
a hormone believed to have protective effects against the disease,
a Canadian research team has learned.
Researchers at Mount Sinai Hospital's Samuel Lunenfeld Research
Institute in Toronto have completed a study of how light and other
factors, such as physical activity, influence the production of
melatonin - a hormone released mainly at night in the absence of
light and believed to protect against breast cancer. The findings
of the study have been published in the December 1, 2005 edition of
the American Journal of Epidemiology.
The study is among the first to demonstrate the role of physical
activity in potentially modifying melatonin levels, thus creating
biological evidence for a reduced risk of breast cancer among women
who exercise regularly.
"If we know that increased melatonin production could be an
underlying reason for the protective effects of physical activity
against breast cancer, then there is great opportunity for the
scientific community to build on this knowledge and help women
understand what steps they can take to reduce their risk of
developing the disease," said Dr.
Julia Knight, the study's lead
investigator at the Samuel Lunenfeld Research Institute at Mount
Sinai Hospital and a University of Toronto professor in the
Department of Public Health Sciences.
The study, funded through the Canadian Breast Cancer Research
Alliance with special funding from the Canadian Breast Cancer
Foundation-Ontario Chapter to study the modifiable risk factors for
breast cancer, took place between 2002 and 2004 and involved the
participation of 213 female volunteers whose melatonin levels were
monitored over time.
"Our focus on primary prevention research was initiated with the
long-term goal of building knowledge about how to stop breast
cancer before it starts," said Sharon Wood, Executive Director of
the Canadian Breast Cancer Foundation-Ontario Chapter. "We are
encouraged by the findings of Dr.
Knight's work, which could
provide momentum for lifestyle changes that could lead to a
healthier population and potentially reduce the incidence of breast
cancer."
University of Toronto
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